Which statement is correct regarding breast cancer genetic susceptibility?

The statement that BRCA mutations confer increased risk for breast and ovarian cancer is correct because research has shown that mutations in the BRCA1 and BRCA2 genes significantly increase the likelihood of developing these types of cancers. These genes are responsible for producing proteins that help repair damaged DNA, and when they are mutated, this repair process is compromised, leading to greater susceptibility to cancer. Women with BRCA1 mutations have a higher lifetime risk of breast cancer, estimated at around 55-65%, and an increased risk of ovarian cancer as well.

Understanding the role of genetic mutations like BRCA is crucial for breast cancer risk assessments and informing screening strategies. Genetic testing for these mutations allows for better risk management, including options for increased surveillance or preventive measures for those with a family history of breast and ovarian cancer.